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4 days ago Β· The meaning of OPTIMIZE is to make as perfect, effective, or functional as possible. How to use optimize in a sentence. Find 53 different ways to say OPTIMIZE, along with antonyms, related words, and example sentences at Thesaurus.com. We need to optimize our use of the existing technology. If you optimize the production process you could speed up the assembly line dramatically. Trailers have also long been optimized to reach their β¦ To optimize a plan, system, or machine means to arrange or design it so that it operates as smoothly and efficiently as possible. Optimize definition: To make as perfect or effective as possible. OPTIMIZE definition: to make as effective, perfect, or useful as possible. See examples of optimize used in a sentence. There are five meanings listed in OED's entry for the verb optimize, two of which are labelled obsolete. See βMeaning & useβ for definitions, usage, and quotation evidence. optimize verb also British optimise / ΛΙΛptΙΛmaΙͺz/ optimizes; optimized; optimizing Britannica Dictionary definition of OPTIMIZE [+ object] formal : to make (something) as good or as effective as possible.